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Xiao J, Zhang R, Huang F, Liu L, Deng Y, Ma Y, Wei Z, Tang X, Zhang Y, Zhang M (2017) Lychee Pulp Phenolic Extract Confers a Protective Activity against Alcoholic Liver Disease in Mice by Alleviating Mitochondrial Dysfunction

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There is also a specific biological reason the systemic route attracted attention

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[DOI] [PubMed] [Google Scholar] 100.IARC Working Group on the Evaluation of Carcinogenic Risks to Humans